Academic Staff Profiles

Dr. Angelo Karunaratne

Senior Lecturer in Department of Mechanical Engineering,University of Moratuwa,Katubedda, Sri Lanka.10400+94 766602008 (Mobile)

Teaching and Administrative Work: 

Curriculum development for Bio-medical Engineering stream

Research Activities : 

Research Themes

  • Tissue Biomechanics - Mechanical and structural relationships of biological tissues - collaboration with Imperial College London and Diamond Light Source UK
  • Heterotrophic Ossification (the formation of mature lamellar bone in extra-skeletal soft tissues) - Mechanical testing combine with multiscale imaging techniques will be applied to bone specimens exercised from Sri Lankan Army amputees to investigate its molecular, nano and micro structure.
  • Bone quality changes during disease conditions - In order to detect bone diseases at early stage  and to measure efficacy of drug treatment more efficiently bone quality changes need to be investigaed. 

Education and Training : 

  • PhD. in Material Science and Bio-medical Engineering, Nov 2012 - 2009 - 2012 - Queen Mary, University of London
  • Masters Degree in Medical Engineering (MEng), July 2009 - 2005 - 2009 - Queen Mary, University of London

Career : 

Professional Qualifications:

  • Chartered Institute of Management Accountants (CIMA) - 2004 – 2005 - May 2005 - Managerial Level                                        
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Memberships of Technical and Professional Organizations:

  • International Union of Crystallography
  • European Society of Calcified Tissues
  • European Society of Biomechanics
  • Material Research Society
  • Bone Research Society

  Career History:

  • Oct 2012 – Dec 2015, Research Associate, Centre of Blast Injury studies, Department of Bioengineering, Imperial College London. 
  • April 2012 – Sep 2012, Knowledge Transfer Research Assistant, Diamond Light Source Ltd, Harwell, under the Impact QM Scholarship 2012.
  • Oct 2009 – Apr 2012, - Ph.D. Tutorial lecturer, School of Engineering and Material Sciences, Queen Mary University of London.
  • Jul 2009 – Oct 2009 Research and Development – Internship, R&D Department, Depuy, Leeds, UK.

Honours and Awards : 

Awards:

  1. Young Investigator Award (Merit) for the work on “Synchrotron nano-mechanical imaging techniques to understand how altered bone quality increases fracture risk in secondary osteoporosis” The award was presented at International conference of Biomedical Engineering in Singapore, December 2013.
  2. Best Doctoral Thesis in Biomechanics – The thesis title - ‘Analysis of alterations in matrix quality at nanoscale in metabolic bone diseases using synchrotron x-ray diffraction’. The award was judged by an ad hoc Award Committee appointed by the European Society of Biomechanics Council and chaired by the ESB Awards Committee Chairman. I have given keynote lecture at the ESB Congress in Greece August 2013.
  3. Best poster prize – The poster title: Mechanical tester for I22 - in-situ mechanical testing with synchrotron microfocus SAXS on biological tissues.  Poster presented at the Science Away Day, Science Division, Diamond Light Source Ltd, UK. Jun 11/2012
  4. European Society of Biomechanics Travel Award for the best abstracts - The abstract title “Hypophosphatemic rickets is associated with disruption of mineral orientation at the nanoscale in the flat scapular bones of rachitic mice with development” submitted to European Society of Biomechanics annual meeting 2012. Jun 30 – Jul 04/2012
  5. Best poster prize: Poster presented at the Bone Research Society/British Orthopaedic Research Society Joint Meeting, Cambridge, UK. Jun 27-29/2011
  6. ASBMR Young Investigator Travel Award for the best abstracts - The abstract, “In-situ synchrotron SAXS Combined with Micromechanical Testing to serve as an In-Vitro Nanomechanical Functional Imaging Technique to Measure the Bone Quality Degradation in Metabolic Bone Diseases” submitted to the American Society of Bone and Mineral Research annual meeting 2011. Sep 16-20/2011

 Media Coverage:

Publications : 

Peer reviewed journals:

  1. A Karunaratne et al, Significant deterioration in nanomechanical quality occurs through incomplete extrafibrillar mineralization in Rachitic bone: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging, J Bone Miner Res. 2012 27(4):876-90.
  2. A Karunaratne et al, Hypophosphatemic rickets is associated with disruption of muscle stress-mediated mineral orientation at the nanoscale in the flat scapular bones of rachitic mice with development, Bone. 2012 vol.51(3):p. 553-62
  3. A Karunaratne et al, Symmetrically reduced stiffness and increased extensibility in compression and tension at the mineralized fibrillar level in rachitic bone, Bone. 2013vol. 52, (2) p.689-698.
  4. H. S. Gupta and A Karunaratne et alIntrafibrillar plasticity through mineral/collagen sliding is the dominant mechanism for the extreme toughness of antler bone,  J Mech Behav Biomed Mater. vol. 28, 2013, p.366 – 382.
  5. A Karunaratne et al, Synchrotron X-ray Nanomechanical Imaging of Mineralized Fibre Composites, 2013. Methods in enzymology, vol: Research methods in biomineralization science.  
  6. Guerette, P.A., et al., Integrative and comparative analysis of coiled-coil based marine snail egg cases - a model for biomimetic elastomers. Biomaterials Science, 2014. vol. 2, p. 710 - 722
  7. A Karunaratne et al., Synchrotron Nano-Mechanical Imaging Techniques to Understand How Altered Bone Quality Increases Fracture Risk in Secondary Osteoporosis, in The 15th International Conference on Biomedical Engineering, J. Goh, Editor. 2014, Springer International Publishing. p. 24-27.
  8. T. J. Bonner and A. Karunaratne et al, Strain-rate sensitivity of the lateral collateral ligament of the knee, J Mech Behav Biomed Mater. 2015. vol 41, p. 261–270
  9. A Karunaratne et al, Multiscale alterations in bone matrix quality increased fragility in steroid induced osteoporosis, Bone. 2016. vol 84, p. 15 - 24

  Guest lectures:

  1. A Karuanratne et al, Effects of disease induced bone matrix quality alterations on bone fracture risk: Insight from synchrotron X-ray imaging combined with micromechanical testing. Invited guest lecture at Science away day of Diamond Light Source Ltd. Oxfordshire, UK, 09/06/2013.
  2. A Karuanratne et al. Importance of structure function relationship of connective tissues - in detecting metabolic diseases and development of better mitigation techniques for service men  and women. Invited talkat Newcastle University International, Singapore (NUIS), Singapore. 03/12/2013
  3. A Karuanratne et al. Evaluation of Bone Fracture and Load Transfer Mechanisms of Lower Limb Injuries from Under Vehicle Explosions, Invited talkat Bioengineering Science Research Group, Faculty of Engineering and the Environment, University of Southampton, UK. 09/10/2013
  4. A Karuanratne et al. Analysis of alterations in matrix quality at nanoscale in metabolic bone diseases using synchrotron x-ray diffraction, Keynote speech forthe Best Doctoral these award at the European Society of Biomechanics, Patras, Greece, 25-28/09 2013

  Peer Reviewed International Conference presentations:

  1. A Karunaratne et al. Bone fracture at blast loading rates. Oral presentation at European Society of Biomechanics, Prague, Czech Republic. 07/2015.
  2. A Karunaratne et al. Structure-function relationship of ligaments is strain rate dependent: Evidence from in-situ synchrotron X-ray diffraction and computational modelling. Oral presentation at Computer Methods in Biomechanics and Biomedical engineering. Amsterdam, Netherlands. 10/2014.
  3. A Karunaratne et al. The structure-function relationships of human cortical bone are strain rate dependent: Insight from synchrotron X-ray imaging combined with micromechanical testing. Oral presentation at International Research council on Biomechanics of Injury meeting in Berlin, Germany 09/2014.
  4. A Karunaratne et al. Structure-function relationship of ligaments is strain rate dependent: Evidence from mechanical testing combined with X-ray diffraction. Poster presentation at World Congress of Biomechanics in Boston, USA. 07/2014.
  5. A Karunaratne et al. Evaluation of Bone Fracture and Load Transfer Mechanisms of Lower Limb Injuries from Under Vehicle Explosions. Oral presentation at International conference of Biomedical Engineering in Singapore, 12/2013.
  6. A Karuanratne et al. Increased stiffness at the fibrillar levelin a murine bone model for ageing, Oral presentation at the European Society of Biomechanics, Patras, Greece, 09/2013
  7. A Karunaratne et al. Investigation of nanomechanical behavior in metabolic bone disease phenotypes using synchrotron X-ray diffraction,Contributed talk and poster presentation at the S4SAS user meeting and workshop, Sheffield, UK, 03/2013
  8. A Karunaratne et al. Investigating the nano-structural and mechanical behavior in the mineralized matrix of metabolic bone disease phenotypes using synchrotron X-ray diffraction, Keynote speech at the Medicine symposium, International small angle X-ray scattering conference, Sydney, Australia, 11/2012.
  9. A Karunaratne et al. Mechanical tester for I22 - in-situ mechanical testing with synchrotron microfocus SAXS on biological tissues, Poster presented at the Science Away Day, Science Division, Diamond Light Source Ltd, Oxford, UK, 06/2012.
  10. A Karunaratne et al. Disruption in fibrillar level fracture mechanisms in rachitic mice bone: measured using in-situ cantilever bending with microfocus SAXD, Poster presented at the European Society of Calcified Tissues, 39th Congress 2012. Stockholm, Sweden, 05/2012.
  11. A Karunaratne et al.Functional link between material level structural alterations in steroid induced osteoporotic bone and its increased fragility. Oral presentation at Material Research Society spring meeting 2012, San Francisco, USA. April 8-13/2012
  12. A Karunaratne et al. Rickets induces significant deterioration in nanomechanical quality through incomplete extrafibrillar mineralization: evidence from in-situ synchrotron X-ray scattering and backscattered electron imaging. Poster presented at the Bone Research Society/British Orthopaedic Research Society Joint Meeting, Cambridge, UK. June 27-29/2011.
  13. A Karunaratne et al. Nano-scale deformation mechanisms in a mouse model of rickets using in-situ tensile testing and Synchrotron SAXS. Poster presented at the Synchrotron User Meeting at Diamond Light Source, Harwell, UK. September 08-09/2011. 
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Research Opportunities: 

MSc, MPhil or PhD opportunity in Biomedical Engineering Applications

We invite applications from highly motivated and enthusiastic candidates to pursue a fulltime MSc, MPhil or a PhD under the project title entitle “Mechanical tester for biomedical engineering applications” with Dr. Angelo Karunaratne, in the Department of Mechanical Engineering at the Unversity of Moratuwa, Sri Lanka.

This project aims to develop a mechanical test rig combined with imaging techniques to investigate bone quality (mechanical and structural) alterations during disease conditions at physiologically relevant loading rates. Successful candidate will receive a full stipend and research funding to continue MSc, MPhil or a PhD. Also during this project student will be able to perform experiments at cutting edge research facilities (Diamond Light Source Ltd.) in the United Kingdom.

More Details: 

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